A word about methylation

 

Methylation-Cycle2Methylation is  critical to countless functions in your body such as: thinking, repairing DNA, turning on and off genes, fighting infections and getting rid of environmental toxins to name a few.

Methylation Defects are tied to Many Conditions

  • Insomnia
  • Autism
  • Frequent miscarriages
  • Bipolar or manic depression
  • Allergies or Multiple Chemical Sensitivities
  • Atherosclerosis
  • Autoimmune Disorders
  • Hashimoto’s or Hypothyroidism
  • ADD or ADHD
  • Lyme Disease (tick borne illness compounded by MTHFR)
  • Chronic Viral Infections
  • To name a few..

Your ability to methylate helps you process toxins and hormones. For example, estrogen… you make it in your body, and you also get it from chemicals in your environment and food etc…if you can’t break down estrogen and get it OUT of your body, you could develop all sorts of disorders.

Methylation also plays a role in making and breaking down various neurotransmitters, epinephrine and melatonin.  If there’s a problem breaking neurotransmitters down, the excess may cause insomnia, panic attacks, and anger.

Such as sufferers of Mold/ Pollen/ Hay Fever, Digestive problems, brain fog, cardiac disease, Children with autism, anyone with a seizure disorder, neurological condition, Alzheimer’s disease, cancer, severe Lyme disease, chronic infections, immune deficiencies, diabetes, food allergies, fertility issues, miscarriages, chronic fatigue, anxiety or any psychiatric illness. Or if you are extremely sensitive to medication, you may have a methylation problem, too.

Problems in the methylation pathway are not always genetic traits.  In any case, it may cause a deficiency of methyl-folate leading to a deficiency of glutathione. Glutathione is known as the ‘master antioxidant’ of the body. Low levels of glutathione can look like chronic fatigue syndrome or fibromyalgia, autoimmune disease states, multiple chemical sensitivities, and progressive diseases like ALS, MS, Parkinson’s, etc.

About 50 % of the US population has a MTHFR defect.

MTHFR MUTATIONS

MTHFR are C677T and A1298C. You may have any combination of these mutations depending on the genetic makeup of your biological parents. Or you do not have the defect at all.  You can do a simple lab test to determine MTHFR snps, or more comprehensive genetic testing helps you find other areas of concern.

Because people with a methylation difficulty have trouble eliminating poisons, these build up in the body and contribute to many health concerns. If a body can’t methylate properly, you cannot use and absorb vital nutrients needed to keep cells healthy and protected.

Things that Interfere with Your Methylation Pathway include

  • Poor diet, poor probiotic status, digestive issues, medications, medical conditions such as autoimmune diseases, and other things that may cause nutrient deficiencies.
  • Xenobiotics
  • Taking medications that deplete vital nutrients. (like metformin, antacids, PPIs, steroids, estrogen-containing drugs and NO)
  • Drinking alcohol stops methylation and depletes glutathione
  • Stimulants like coffee and metabolism boosters use up your methylation pathway nutrients too quickly
  • Lyme disease, and the Borrelia burgdorferi bacteria feeds on magnesium and uses the magnesium to make biofilms and hide. Low Mg reduces your ability to methylate.
  • Taking poor quality nutrients that deplete methyl groups
  • Heavy metals like mercury, lead, cadmium, copper, or arsenic, etc.
  • High levels of acetylaldehyde, a  neurotoxin released by Candida
  • Anxiety or a lot of stress.

Medications that Make MTHFR Much Worse

  • Acid blockers and Antacids deplete your probiotics, and suppress your ability to make B12 and absorb minerals as well as reduce immunity.
  • Cholesterol-binding drugs rob the body of essential vitamin A, D, E and K, and reduce absorption of nutrients from food. 
  • Nitrous oxide it inactivates an enzymes
  • Niacin in High doses will deplete SAMe and reduce B6. BUT can be used good if you are over-methylating! 
  • Birth control and menopause hormones rob the body of necessary folate
  • Sulfa-containing antibiotics inhibit the enzyme DHFR which makes methylation problems.
  • Metformin robs the body of methyl B12
  • Do not stop ANY medications without discussing with your prescriber

Start in the Gut with High-quality probiotics, which are incredibly important to people with a methylation problem to optimize gut flora and minimize candida.

  • If you’ve taken an antibiotic for more than a week, you are low in probiotics.
  • If you have had your appendix removed, you are deficient in probiotics (and thus at higher risk for Candida).
  • If you drink a lot of coffee
  • If you have recurrent vaginal yeast infections
  • If you have a lot of flatulence
  • If you crave sweets or have a white coating on your tongue

A (bad) word about FOLIC ACID

Folic acid, is not what your body uses.  Natural folate comes from the foods that you eat. The body uses methyl-folate, or L5-MTHF, not folic acid.

Anyone with a methylation defect should avoid Folic acid at all cost in the diet, supplements, products etc.

In fact ALL B vitamins should be methylated from this point. Using a CYANOB 12 can actually result in the production of cyanide!!

What else can you do?

  1. Contact your local MTHFR EDUCATED doctor
  2. Repair cell membranes
  3. Consider methylation support needed to maximize your health
  4.  Avoid foods containing enriched folic acid, preservatives, poisons, pesticides and artificial anything
  5. Minimize or avoid any form of alcohol
  6. Take high quality supplements provided by your doctor to minimizes oxidative stress
  7. Do a lab test or 23andme

Genes are just switches, they can be turned on and off with your lifestyle.

We are not victims to our genes!

Gluten-free its easy!!.Why must we eliminate gluten?

 

gf

THE GUT

  • The gut does more than absorb food
  • It is the first line of defense in the immune system.
  • Mis-education can cause autoimmune diseases
  • Gluten filled grains should be avoided like Wheat, rye, barley and their cross contaminating cousins corn, and sorghum may all play a role in triggering these dynamic gut changes.
  • There also may be Cross-reactivity and stimulation of allergens by other foods like dairy, soy, corn, and pork.
  • Immune activation causes changes in gut permeability and blood brain permeability. This allows for the passage of toxins into areas that are not equipped to eliminate them and may play a significant role in depression.

THE IMMUNE SYSTEM

  • Once gluten has reached the gut mucosa, it can stimulate production of antibodies.
  • TTG (Tissue trans-glutaminase) is an enzyme that plays an important role in the immune system of the gut. And a Marker for Celiac Disease.
  • TTG is active in the central nervous system, and high levels can cause a host of symptoms  including depression, seizures, headaches, multiple sclerosis/demyelination, anxiety, ADHD, and ataxia.
  • 51% of the Celiac population develops neurologic or psychiatric dysfunction, as well as neuropathy which has been found to be resolved by reducing gluten exposure.
  • There is a high incidence of positive antibodies in schizophrenics.
  • An important note is Neurological Symptoms usually present in the absence of any reportable gastrointestinal symptoms.

THE THYROID

  • Autoimmune thyroid disease occurs in high rates among Celiac and gluten sensitive individuals.
  • Researchers have identified shared pathology to these two conditions.
  • The inflammatory cytokines cause immune reactivity in Celiac disease and Hashimoto’s thyroiditis.

CONCERNS with INGESTION

* Gluten can travel through the blood stream can stimulate opiate receptors in the brain resulting in GLUTA-mophone.

* The effects of this stimulation may have wide-ranging psychiatric manifestations, including addiction potential of these foods.

* Those eating high gluten diets can expect to undergo 1-3 weeks of withdrawal.

* Gluten containing foods contain high levels of lectin. Lectin is used in pesticides.

* Lectin promotes intestinal inflammation and permeability, which then can cause wide-spread and varied organ damage by binding with sugars in body tissues.

GMO Concerns

  • Bt-toxin and glyphosate are two poisons heavily employed in the production of genetically modified crops.  Bt-toxin causes perforating effects on insect digestive tracts and has been found in fetal circulation
  • RoundUp, weed killer, has active bacteria-killing and inflammatory effects in our guts, over use has allowed this in the ground water supply, further polluting the crops.
  • Vegetable oils, soy, corn, and animals consuming corn products are everywhere in the standard American diet, which likely perpetuates gut dysfunction and accelerated gluten sensitivity.

KNOWLEDGE AND HEALING

  • Lab testing called “Celiac panel” are only test for alpha gliadin, tissue transglutaminase 2, and endomesial antibody.
  • IgG allergy testing tests gut reaction to wheat/gluten
  • 23andme tests metabolic markers and defects

CONCLUSION

Some degree of gluten reactivity is thought to occur in up to 80% of the population.

Response to gluten free diets and reduction of inflammation is remarkable and extraordinarily beneficial.

Celiac incidence has increased by more than 400% in the past 50 years; likely as an adaptive mechanism to decrease environmental toxicity.

Why Methylation matters

Methylation-Walsh

What is methylation? In scientific terms it’s addition of a Methyl group to a protein (a methyl group is single carbon and three hydrogen atoms). In over simplified terms it’s the first domino in a series of dominos of the detox pathways.  It is a facet in how the body eliminates toxins, repairs cells, manufactures cells and utilizes energy.

Methyl groups control:

  • Genetic expression and the repair of DNA
  • The stress response
  • The production and utilization of glutathione
  • The detoxification of toxins like hormones, chemicals and heavy metals
  • The inflammation response
  • Neurotransmitter manufacturing and breakdown
  • Energy production
  • The repair of damaged cells
  • The immune system and immunity

 

When the methylation cycle is impaired, any or all of these processes can become compromised, and a cascade of event can occur causing dis-ease and illness.

Methylation and glutathione

Glutathione is the body’s master antioxidant, in charge of all cellular repairs. The main focus of methylation is to produce glutathione. Glutathione directly neutralizes toxins, and reduces cellular inflammation, among other important processes.  Ideally, the body makes its own glutathione from other amino acids found in food and, then recycles it via methylation using methyl donors like vitamin B12, and folate. When there are a lot of toxins in the body, or a part of the methylation cycle is disrupted, illness can occur.

Improve Methylation

  • Eat Folate rich foods, natural methyl donors flood the body with all the important nutrients needed to methylate properly.
  • Take the proper B vitamins for you. EveryBody has different methylation needs and requires different nutrient levels. Discuss with your methylation savvy provider as to what is the best balance for you.
  • Be sure to get adequate minerals such as magnesium and zinc. When methylation is impaired the body uses up these minerals as cofactors faster; When digestion is impaired the body doesn’t digest these minerals adequately. Support proper methylation by making sure there are adequate amounts of these minerals in your diet.
  • To assist in optimizing digestion, take quality probiotics.
  • Reduce stress, eliminate alcohol, smoking and toxins, all of these toxins alter methylation and use up necessary methyl groups.

 

To support proper methylation naturally boost your glutathione

  • Sources of these important amino acids to boost glutathione include organic pastured eggs, wild caught fish and organic lean meats.
  • Eating high sulfur-containing foods is vital, try some extra garlic and onions and other cruciferous vegetables.
  • Organic Un-denatured whey protein powder boosts glutathione levels by converting cysteine into glutathione. However if dairy sensitive this is not a good choice.
  • Include antioxidant rich foods, full of Vitamin C, D and E, they all boost glutathione levels
  • Exercise helps reducing stress and depression, AND it also boosts your glutathione levels and improves detoxification.
  • Lack of sleep can deplete glutathione. Make sure to sleep well.
  • Consider Curcumin! Delicious Turmeric raises glutathione levels. Be sure to take it with a healthy fat for best digestion and absorption.

 

Typical lifestyle modifications to improve methylation or life in general; include avoiding toxins, minimizing stress, sleeping well, optimizing digestion and consuming a nutrient dense diverse diet. Proper supplements to support methylation and glutathione can assist the body’s ability to naturally detoxify and heal. Please not that for methylation challenges there is no “one size fits all” approach and common recommendations may cause adverse effects in a methylation challenged individual. Always seek a qualified provider to begin your journey to cellular healing.

 

Why do I care about this MTHFR?

mthfr img
The MTHFR gene is responsible for making a functional MTHFR enzyme. This enzyme is a key regulatory enzyme in the metabolism of folate, and the gene itself has a very important and complex role. If the MTHFR gene is mutated, the MTHFR enzyme will not function properly.

A MTHFR mutation inhibits the body’s ability to methylate, or convert pharmaceutical folic acid into Methylfolate. Methylfolate is the active and usable form of folate, and if the body is not getting enough of this folate at the cellular level, it leads to deficiencies and a multitude of health issues.

Folic Acid is actually a synthetic form of folate, produced in a lab and not found in nature. The conversion of Folic acid into the usable form of methyl folate requires a complex 4 step process, not properly preformed in individuals with a MTHFR mutation.
The most common MTHFR gene mutations are found at position C677T and/or position A1298C on the MTHFR gene located on chromosome 1, and passed from biological parents. So each individual can have UP to 2 copies of the Mutation:

Homozygous Mutation: 2 affected genes on either the 677t or the 1298c position. MTHFR enzyme will only run at about 10% efficiency (or 90% impaired).
Compound Heterozygous Mutation: 1 affected gene on the 677t gene and 1 mutation of the 1298c gene. This combination can be more severe, due to the fact that both gene defects are present. 98% of autistic children have this mutation.
Heterozygous Mutation: most common and less severe of all the mutations. It means there is 1 normal gene and 1 mutated gene. The mutation will either be on the 677 or the 1298 position. The MTHFR enzyme will run at about 40%-60% efficiency compared to normal MTHFR enzymes.

The Mutations….
677t Mutation – This mutation is most commonly associated with heart disease, heart attack, stroke, blood clots, peripheral neuropathy, anemia, miscarriages, tongue tie, congenital birth defects, to name a few.
1298c Mutation – This mutation is most commonly associated with chronic illnesses, such as; depression, fibromyalgia, chronic fatigue syndrome, migraines, Irritable Bowel Syndrome, Memory loss, Alzheimer’s and Dementia, OCD, Bipolar, Schizophrenia, to name a few.

Methylation
The Methylation Cycle is a major biochemical pathway in our bodies that contributes to a wide range of crucial body functions, such as detoxification, immune function, mood balancing, and more. When the MTHFR pathway is impaired by mutations, other pathways are also affected, and the entire body, can suffer the consequences of “oxidative stress” (toxin buildup). Other pathways do exist for these metabolic processes, however they use more energy and create more “cellular waste” than necessary..causing more “oxidative stress”.

Pathways affected by MTHFR
1) Glutathione is the key antioxidant and detoxifier in our body, so when its production is hindered, one is more susceptible to “oxidative stress” and less tolerant to toxins, like heavy metals. With age the accumulation of heavy metals and toxins grows, and may lead to a multitude of symptoms including chronic disease, rashes, premature aging, depression, and anxiety, to name a few…
2) A lack of methylfolate also hinders the multi-step process that converts homocysteine, to methionine. Homocysteine, then builds up in the bloodstream, and reduces the amount of methionine. Methionine is necessary to produce proteins and assist in breaking down histamine, serotonin, and dopamine.

MTHFR and Pregnancy
Elevated homocysteine levels caused by MTHFR mutations can lead to formation of blood clots. This is especially a cause of concern during pregnancy, and can lead to miscarriages, clotting poroblems and fertility challenges. There are various forms of MTHFR mutations, and some are more serious than others during a pregnancy, check with a provider for medical counsel on this topic. Women who experience RPL (repeated pregnancy loss) will be tested for MTHFR.
Elevated homocysteine is also frequently found in pregnant woman who experience preeclampsia, placental abruption, giving birth to low-birth-weight baby (IUGR), and neural tube defects (an abnormality of the fetal spine or brain). So it is extremely important to make sure homocysteine levels are normal during pregnancy, in the presence of MTHFR.

Treatment
Conventional protocol for MTHFR mutations, especially during pregnancy is a mega dose of folic acid, usually around 5mg. As previously mentioned this simply accelerates “oxidative stress” and further complicates the problem. MTHFR mutations are not a “one size fits all”. With a MTHFR mutation, stay away from folic acid. Educate yourself, eat a Clean Diet, Sleep Well, Exercise, get fresh air and release stress. See your favorite MTHFR educated provider for the best advice on supplementing if necessary.

Probiotics are not all treated equally

probiotics
It is no secret that probiotics are an integral part of healing and health maintenance for every body! The variety of strains and choices can sometimes confuse the naïve or “unprofessed vitamin snob”. Probiotics are NOT all the same!
As of recent, researchers are taking quite an interest in probiotic strains and their effects on human microbiome and ultimately health. In recent years there has been a surge in the study of specific strain probiotics, the human microbiota, and other related applications. The World Health Organization defines probiotics as “live organisms which when administered in adequate amounts confer a health benefit to the host”.
Probiotics can kill pathogens by positively stimulating the immune system, balancing the gut microbes by secreting or inhibiting certain chemokines and supporting the inhibition of pathogens.
Check out this list to see which specific strains of probiotics can treat conditions.
Diarrhea caused by too many antibiotics-Lactobacillus rhamnosus GG, when given at the same time as antibiotics, had a greater than 60% reduced risk of antibiotic-associated diarrhea.
Anxiety- research has shown Lactobacillus helveticus R0052 and Bifidobacterium longum R0175 are effective in clearing high levels of anxiety provoking neurochemicals from the gut!
Colic or Infant Reflux
• Bifidobacterium breve PXN 25
• Lactobacillus reuteri Protectis
• Bifidobacterium infantis PXN 27
• Lactobacillus acidophilus PXN 35
• Lactobacillus casei PXN 37
• Lactobacillus rhamnosus PXN 54
• Streptococcus thermophilus PXN 66
Found in a selection of probiotic powders carried hereour custom supplements

Constipation

Although Constipation has many causes, such a poor digestion, dehydration, ingestion of food allergens; to name a few. Probiotics play and integral role in optimizing digestion. Some of the Probiotic strains studied to help constipation include:
• Bifidobacterium breve PXN 25
• Bifidobacterium infantis PXN 27
• Lactobacillus acidophilus PXN 35
• Lactobacillus casei PXN 37
• Lactobacillus rhamnosus PXN 54
• Streptococcus thermophilus PXN 66
Found in a selection of probiotic tablets carried here our custom supplements
Dental Caries and Cavities
We all know that balanced digestion, proper mineral assimilation and probiotics play a role in healthy tooth development and maintenance. To reduce the incidence of dental caries and cavities try:
Streptococcus Salivarius 14685 Found in our product called “PRO-TOOTH”

Eczema
Although in many cases there is no simple answer, a good start to healing eczema is a quality probiotic that can include some of these strains:
• Bifidobacterium breve PXN 25
• Bifidobacterium infantis PXN 27
• Lactobacillus acidophilus PXN 35
• Lactobacillus casei PXN 37
• Lactobacillus rhamnosus PXN 54
Found in a selection of probiotic powders, chewables and tablets carried at the FWC

Start your healing today with probiotics!
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3182331/
http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2036.2012.05104.x/full#apt5104-sec-0015
Videlock, E. J. and Cremonini, F. (2012), Meta-analysis: probiotics in antibiotic-associated diarrhoea. Alimentary Pharmacology & Therapeutics, 35: 1355–1369. doi: 10.1111/j.1365-2036.2012.05104.x
http://www.ncbi.nlm.nih.gov/pubmed/11799281
http://drprobiotikum.hu/docs/synbiotics-in-managment-of-infantile%20colic.pdf
http://www.ncbi.nlm.nih.gov/pubmed/20974015
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3446166/

Fever

It’s not unusual for children to have very high fevers. In fact, it is generally very helpful for kids to get robust fevers, as it signals a strong immune response which can quickly eliminate pathogens in a short period of time. A fever isn’t intrinsically dangerous until it reaches over 106° F at that point brain damage can occur. Febrile seizures can occur at temperatures below this point and may be related to a genetic predisposition. Febrile seizures in otherwise normal children can be safe.
Here are some guidelines for managing a high fever:
• Pay attention to how the child is looking/feeling than what the thermometer says. Use parental instincts and your own sense of touch to decipher how hot the fever is burning.
• Typical fevers range between 100.6 and 104° F
• Fevers around 105°F-106°F usually indicate a severe bacterial infection and should be evaluated
• High fevers in pregnant women are of concern, and should be evaluated.
• The brain has a set-point at which fever stops rising. It is a myth that offering a fever reducer will stop the infection. In fact it suppresses the immune system and allows the infection to strengthen. Cytokines that target infection work best at an elevated temp!
• High fevers that last over 4 days or a fever in a newborn should be evaluated by a healthcare provider immediately.
• Febrile Seizures- THIS IS TERRIFYING, but generally harmless. These seizures DO NOT result in brain damage; they can last a few seconds to a few minutes and can occur in 4% of the population between the temperature ranges of 101°F-103°F and febrile seizures only occur in kids’ ages 6 months to 5 years old. Fever reducers DO NOT prevent febrile seizures. General protocol is to have a child evaluated by a health care provider if they have a febrile seizure.
Avoiding a fever reducer is during a fever is very plausible. Acetaminophen is hugely liver toxic; it is the number one cause of liver failure in the UK, and the number two cause in the US. The way Acetaminophen/ Paracetamol are metabolized requires huge amounts of glutathione in order to make it less toxic. Acetaminophen is infamous for depleting glutathione. Acetaminophen overdoses can occur at remarkably low doses compared to other pharmaceuticals, can cause massive liver damage.

The constituents in Acetaminophen/Paracetamol require huge amounts of Glutathione to be eliminated from the cells; leaving excess free radicals. These Free radicals cause DNA and cellular damage, made worse by methylation defects such as MTHFR.
Another problem is that acetaminophen is in many combination products, including over the counter cough syrups, pain formulas, allergy medicines and more. So any chance we get to avoid liver damage in small children gives our kids an advantage in healing.

FEVER FACTs
• Fevers only need to be treated if they cause discomfort. Usually fevers don’t cause any discomfort until they go above 102° or 103° F. it is rare to have a high fever above 105°F, and are generally they are harmless.
• With pharmaceutical treatment, fevers only reduce by 1° or 2°
• Without pharmaceutical treatment fevers will normally last for 2 or 3 days until the body fights off the infection.
• The body’s temperature normally changes throughout the day. It peaks in the late afternoon and evening. An actual low-grade fever is around 101° F
• Try “Wet Socks”, homeopathy, chiropractic adjustments or tepid baths as a natural way to comfort a child with a fever.
‪#‎drkendrabecker‬
‪#‎fever‬
‪#‎mthfr‬
‪#‎ilovewatchingyouheal‬
‪#fever

The difference between MethylFolate and Folic acid

But wait! My doctor says Folic acid is important to take!!

Conventional Doctors often use the terms ‘folic acid’ and ‘folate’ interchangeably. However they are not interchangeable. Folic acid refers to the oxidized synthetic pharmaceutical that is added to processed foods and dietary supplements for “food fortification”. Folic acid is synthetic compound manufactured in a laboratory where folate is the naturally occurring, and the body does not utilize them the same.

Human exposure to folic acid was non-existent until its chemical synthesis in 1943. Upon the addition of synthetic folic acid to food by government mandate in 1989, the US has seen a rise in autism, infertility, autoimmune disease and cancers. With a high intake of folic acid in a standard American diet, un-metabolized folic acid could mask a vitamin B12 deficiency which can harm central nervous system function. Taking high doses of synthetic folic acid with a MTHFR mutation blocks the ability to absorb and assimilate natural folate and methylfolate; THIS is a major failing of current widespread medical and prenatal advice.

Science has established that adequate folate intake from the consumption of folate-rich foods is essential for health. Folate aids the complete development of red blood cells, reduces levels of homocysteine in the blood, and supports proper nervous system development and function. Folic acid must undergo initial reduction and methylation in the liver, and then converted to the useable form; this requires a specific enzyme, MTHFR, absent or impaired in up to 60% of the population. The low activity of this enzyme in the human liver, combined with a high intake of folic acid, may result in elevated levels of un-metabolized folic acid entering the systemic circulation; Leading to a whole host of health problems plaguing modern society.

MTHFR, along with other gene mutations and heredity factors, can present special problems in pregnancy and reproduction as well as other serious conditions later in life. This is not to say that these mutations should cause alarm; but if you’re already aware of your genetic status, it would be highly beneficial to take special precautions. A baby can inherit problems in its own DNA, which present symptoms, caused by the nutritional deficiencies present at the time of conception present in the parents. Ensuring proper methylation from the beginning, in a baby, will prevent impaired immunity and virus and heavy metal accumulation from birth. This is an essential component to preventing autism, allergies, asthma and eczema later in life.

Researchers now know that supplementing with the proper forms of Methylated B vitamins can help restore health. However high amounts of folic acid in poor quality supplements AND enriched and fortified foods can be detrimental to health. Another beneficial treatment is to minimize stress in your life and in your cells. Remember to Avoid any and all “oxidative stressors” such as; Smoking, Alcohol, Certain Antibiotics unless absolutely necessary, Nitrous oxide gas (used at the dentist), Foods that cause sensitivities or allergies, Toxins in the environment (pesticides, radiation, EMFs, etc), Heavy metals (like mercury and aluminum) and stress!
‪#‎MTHFR‬ ‪#‎folatevsfolicacid‬ ‪#‎naturalmama‬ ‪#‎naturalpregnancy‬
‪#‎ilovewatchingyouheal‬ ‪#‎drkendrabecker‬

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MTHFR & Male Fertility

Daddy’s Genes Matter!!
So much of the focus on Fertility and MTHFR falls on the mother and her genetic contribution. However 50% of the baby’s genome comes from DAD! We evaluate and scrutinize mom’s diet and yet dad is left alone!

Recently powerful new research on MTHFR mutations and miscarriages implicates the fathers role more than we thought possible. While each parent contributes equal DNA to their offspring, it is women, mothers that come to office visits and comply with recommendations. Next time ladies! Bring your man!

A recent large scale study proved correlation that BOTH the MTHFR C677T and the A1298C contributed from BOTH parents increased risk of miscarriage. Interestingly, babies with 2 copies of the MTHFR A1298c mutation had the highest incidence of miscarriage. 2 copies of a mutation means EACH parent donated one copy! DAD’s Genes matter too!

So here at the FWC our preconception health protocol includes BOTH parents! And the “inception” of the protocol is months before “conception”. A thorough review of lab work, medical conditions, diet, lifestyle and genetics assist in the best possible outcomes.

It is important to note when addressing conception and MTHFR that a good quality diet and proper nutrients including bio-available Folate is included. Folate is what ensures proper functioning DNA and provides the proper signaling for cell differentiation in early pregnancy, as well as protecting sex-cells in BOTH parents from DNA damage. However, Choosing Folate alone will not eliminate poor outcomes.

However we do know Low folate levels are associated with higher incidence of:
• Miscarriage
• Low sperm quality
• Autism
• ADD/ADHD
• Allergies
• Among other conditions
Getting Started!
Begin your road to parenthood months before conceiving. Give the PALEO diet a try. Paleo is a diet chuck full of nutrients and beneficial fat and free of many common allergens and chemicals.
Normalize weight and maintain exercise to help ensure proper function of metabolism, sleep cycles and menstrual cycles (for mama only of course in this instance).
Meet with an educated provider who can run proper lab testing and make recommendations to optimize the best pregnancy outcomes. Remind providers (or find another) that Folic acid is not the optimal form of folate for properly functioning DNA especially in the presence of MTHFR mutation.
Enjoy the journey; becoming a parent is one of the most amazing experiences in a lifetime.

MTHFR..an introduction

Faulty methylation has been linked to heart disease, stroke, reproductive disorders, neurodegenerative diseases like Alzheimer’s, Parkinson’s, ADHD, Autism Spectrum Disorders and fertility issues. It has also been linked to chronic fatigue, anxiety, depression, colon cancer, reproductive cancers, kidney infarct, cervical dysplasia, faulty detoxification and impaired DNA repair.

Methylation occurs when SAMe (S-adenosine methionine) donates a methyl group, which is then attached to the molecule that is being detoxified. SAMe then becomes homocysteine.
Vitamin B6, B12, and folate are necessary to reduce homocysteine and keep the methylation process occurring smoothly.
Methylation is also used in DNA regulation. If you have poor methylation, your cells will not function correctly leading to decline in health.

• MTHFR (Methylenetetrahydrofolate reductase) It is first converted to tetrahydrofolate (THF) then to 5,10-methyleneTHF. MTHFR is needed to further convert 5,10-methyleneTHF into active 5-methylTHF, in order to convert methionine from homocysteine.
• MTR – 5-methyltetrahydrofolate-homocysteine methyltransferase is encoded by the MTR gene. It’s task is to regenerate methionine from homocysteine by using 5-Methyl-THF(levomefolic acid obtained from MTHFR conversion) as a methyl donor. Vitamin B12 is needed.
• MTRR – this gene provides instructions for making methionine synthase reductase. Methionine synthase helps process amino acids, which are the building blocks of proteins. Specifically, it converts the amino acid homocysteine to methionine.
• COMT – catalyzes the transfer of the functional methyl group from S-adenosylmethionine (SAMe) to the desired substrate. COMT snps can cause Impaired neurotransmitter metabolism, Decreased drug metabolism, Decreased detoxification of toxic catecholamine’s from the environment. Correlated with a variety of human disorders, including estrogen-induced cancers, Parkinson’s disease, depression, and hypertension.
• HOMOCYSTEINE- A modified amino acid that is toxic at elevated levels. In high levels can lead to many of the disorders. Homocysteine is not obtained from the diet; For treatment to be effective, levels should be monitored and genetics should be evaluated to properly lower homocysteine.

MTHFR and Chiropractic

 

Recently there has been a lot of talk about MTHFR (methylenetetrahydrofolate reductase gene that contains the DNA code to produce the MTHFR enzyme. This enzyme, simply stated, helps us convert B vitamins into energy inside the cells) When there are mutations or variations in the MTHFR gene, there is enzymatic malfunction or decreased function, this is implicated in everything from serious genetic disorders to no so serious nuisance type problems.
Because MTHFR is genetic, and appears in 60% of the population, there is little we can do about what passes to us from our parents, but a host of things we can do to support functioning of this enzyme and support the proper energy production.
Many factors related to MTHFR, can cause a person to become deficient in vitamins, minerals, amino acids and antioxidants; and conversely have higher levels of inflammation. So the standard clean diet, good sleep, exercise and of course chiropractic apply here..however chiropractic can also be a useful tool in detection of a MTHFR problem.
Nutrient deficiency symptoms vary, but are very apparent to a physician educated about MTHFR. Deficiencies in calcium, magnesium, zinc, N-acetyl cysteine (NAC), glutathione, iron and vitamins B1, B2, B6, B9 (folate), B12, and Vitamin D very common with MTHFR, and can effect chiropractic care. Many of these deficiencies can affect how we heal, perceive pain and even how an individual holds adjustments.
Science has shown us time and again that low Vitamin D levels affect mood and increase pain, low levels of minerals cause muscle spasms, poor sleep and anxiety, and low levels of B vitamins increase our susceptibility to toxins and oxidative stress…all things patients visit the chiropractor for!
In the meantime don’t start guessing where you’re deficient and taking supplements randomly. Listen to your body:

Is your fatigue unrelenting even after treatment? This could mean that your MTHFR mutation gives you the inability to utilize B vitamins properly, and your cells are “starving” for energy.

Are you holding your chiropractic adjustments? If not it is likely your MTHFR issue is causing low mineral levels in your cells.

Are you constantly getting injured or taking an extra-long time to recover? It is likely your levels of inflammation are higher; this alone can lead to long term damage and should be addressed in a timely fashion.

Of course, the best approach is proper diagnosis and treatment by a skilled provider who can educate and empower your healing. Eat well, Sleep Well and of course TURN YOUR POWER ON!!
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