Faulty methylation has been linked to heart disease, stroke, reproductive disorders, neurodegenerative diseases like Alzheimer’s, Parkinson’s, ADHD, Autism Spectrum Disorders and fertility issues. It has also been linked to chronic fatigue, anxiety, depression, colon cancer, reproductive cancers, kidney infarct, cervical dysplasia, faulty detoxification and impaired DNA repair.

Methylation occurs when SAMe (S-adenosine methionine) donates a methyl group, which is then attached to the molecule that is being detoxified. SAMe then becomes homocysteine.
Vitamin B6, B12, and folate are necessary to reduce homocysteine and keep the methylation process occurring smoothly.
Methylation is also used in DNA regulation. If you have poor methylation, your cells will not function correctly leading to decline in health.

• MTHFR (Methylenetetrahydrofolate reductase) It is first converted to tetrahydrofolate (THF) then to 5,10-methyleneTHF. MTHFR is needed to further convert 5,10-methyleneTHF into active 5-methylTHF, in order to convert methionine from homocysteine.
• MTR – 5-methyltetrahydrofolate-homocysteine methyltransferase is encoded by the MTR gene. It’s task is to regenerate methionine from homocysteine by using 5-Methyl-THF(levomefolic acid obtained from MTHFR conversion) as a methyl donor. Vitamin B12 is needed.
• MTRR – this gene provides instructions for making methionine synthase reductase. Methionine synthase helps process amino acids, which are the building blocks of proteins. Specifically, it converts the amino acid homocysteine to methionine.
• COMT – catalyzes the transfer of the functional methyl group from S-adenosylmethionine (SAMe) to the desired substrate. COMT snps can cause Impaired neurotransmitter metabolism, Decreased drug metabolism, Decreased detoxification of toxic catecholamine’s from the environment. Correlated with a variety of human disorders, including estrogen-induced cancers, Parkinson’s disease, depression, and hypertension.
• HOMOCYSTEINE- A modified amino acid that is toxic at elevated levels. In high levels can lead to many of the disorders. Homocysteine is not obtained from the diet; For treatment to be effective, levels should be monitored and genetics should be evaluated to properly lower homocysteine.

MTHFR and Chiropractic


Recently there has been a lot of talk about MTHFR (methylenetetrahydrofolate reductase gene that contains the DNA code to produce the MTHFR enzyme. This enzyme, simply stated, helps us convert B vitamins into energy inside the cells) When there are mutations or variations in the MTHFR gene, there is enzymatic malfunction or decreased function, this is implicated in everything from serious genetic disorders to no so serious nuisance type problems.
Because MTHFR is genetic, and appears in 60% of the population, there is little we can do about what passes to us from our parents, but a host of things we can do to support functioning of this enzyme and support the proper energy production.
Many factors related to MTHFR, can cause a person to become deficient in vitamins, minerals, amino acids and antioxidants; and conversely have higher levels of inflammation. So the standard clean diet, good sleep, exercise and of course chiropractic apply here..however chiropractic can also be a useful tool in detection of a MTHFR problem.
Nutrient deficiency symptoms vary, but are very apparent to a physician educated about MTHFR. Deficiencies in calcium, magnesium, zinc, N-acetyl cysteine (NAC), glutathione, iron and vitamins B1, B2, B6, B9 (folate), B12, and Vitamin D very common with MTHFR, and can effect chiropractic care. Many of these deficiencies can affect how we heal, perceive pain and even how an individual holds adjustments.
Science has shown us time and again that low Vitamin D levels affect mood and increase pain, low levels of minerals cause muscle spasms, poor sleep and anxiety, and low levels of B vitamins increase our susceptibility to toxins and oxidative stress…all things patients visit the chiropractor for!
In the meantime don’t start guessing where you’re deficient and taking supplements randomly. Listen to your body:

Is your fatigue unrelenting even after treatment? This could mean that your MTHFR mutation gives you the inability to utilize B vitamins properly, and your cells are “starving” for energy.

Are you holding your chiropractic adjustments? If not it is likely your MTHFR issue is causing low mineral levels in your cells.

Are you constantly getting injured or taking an extra-long time to recover? It is likely your levels of inflammation are higher; this alone can lead to long term damage and should be addressed in a timely fashion.

Of course, the best approach is proper diagnosis and treatment by a skilled provider who can educate and empower your healing. Eat well, Sleep Well and of course TURN YOUR POWER ON!!
‪#‎mthfr‬ ‪#‎chiropractic‬ ‪#‎turnyourpoweron‬ ‪#‎ilovewatchingyouheal‬‪#‎drkendrabecker‬ ‪#‎sportsmedicine‬



Recently there has been a Nasty Stomach bug going around. It is affecting moms, dads, kids or ALL ages and even pregnant women! It seems to take no prisoners! Here are some useful tips to survive this bug! This bug does not seem to have a particular “person zero “origin that I have found so watch yourselves this bug can last 1 to 10 days, however it seems to be a 3 day average across the board; At least for the most acute aspects of the illness.

Here are some great tips to surviving!
Small sips of Coconut water, or water mixed with maple syrup or even natural gummy bears. All of these sources have high levels of sugar, sugar stabilizes blood-sugar and wards off nausea, it also causes excess fluids to “flood the colon” helping wash out the nasty viral perpetrator that caused this bug.
Another great tip is to prepare a coconut water or maple water “granita” a thin icy treat if even the thought of fluids is nauseating. A good rule of thumb to try is a teaspoon/ gummy every 15 minutes. Remember Fluids keep you hydrated especially when you are sweating, vomiting, and having diarrhea.

As the Nausea subsides, try tea and bone broth, both will help restore the electrolytes lost. As recovery begins try the BRAT Diet – bananas, rice, applesauce, and (gluten free) toast, these foods that are easy to digest, contain a lot of carbohydrates to replenish energy, and restore nutrients lost through vomiting and diarrhea.
Rest is paramount; forget the mounds of laundry you are acquiring. Sleep is the key to a quick recovery. In spite of the fact that it feels like your insides are churning with hot acid, the body needs rest in order to fight off the virus. Get plenty of sleep and reduce the amount of activity you normally do during the day. The body is working hard to fight off the virus and repair damage on the cellular level.

Try some homeopathy! There is little conventional medicine can offer to ameliorate suffering, so here are some tips to getting through it quickly, depending on your symptom picture, here are some suggestions
Ipecacuana- vomiting preceded by much nausea or Persistent nausea and vomiting is its chief indication.
Antimonium crudum -vomiting as soon as he eats or drinks.
Aethusa- when vomiting looks like large green curds of milk, followed by great exhaustion
Phosphorous- vomiting causes great thirst for cold water, but as soon a it becomes warm in the stomach it is vomited.
Iris versicolor-Periodical vomiting spells and especially vomiting of sour matters so sour as to set the teeth on edge.

Doing simple acupressure on the point PC3 (3 finger breaths below the wrist) can reduce the nausea, as well as a cold cloth on the forehead or back of the neck.

Restore with probiotics! As soon as the vomiting stops, boost your immunity and gut with high quality probiotics, this will help restore the proper balance in the gut and (hopefully) insulate the cells to reduce the possibility of this happening again.
Hang in there it will be over quickly, even though it doesn’t feel that way!

Bad Mood? Why?

Methyl Trapping and HIGH AMMONIA!
Methyl trapping is a situation in which folate becomes trapped and unusable by the body. It is defined as a functional folate deficiency, in the presence or absence of a MTHFR mutation. Methyl Trapping alters proper homocysteine metabolism such that folate–dependent synthesis of methionine is compromised.
Methyl trapping was originally described in Down syndrome where plasma levels of homocysteine, and methionine, both which significantly which decrease cellular methylation capacity. Depletion of glutathione (also observed in Down syndrome) due to the presence of an additional CBS mutation, can cause oxidative stress.
Methyl trapping is described as cascade of symptoms, cause by “buildup” of neuro-excitation following supplementation with folate, or B12 or SAMe in an attempt to treat MTHFR SNPs. The consumer, in an attempt to self-diagnose and treat, takes high dose supplements with “active” (or methyl) B vitamins in an incompatible dose or formulation. These individuals may experience varying degrees of neurotoxic symptoms such as unprovoked insomnia, rage, anxiety, brain fog and alcohol intolerance, and other mood lability. In some cases individuals may feel better initially, and experience better mood and energy, quickly to be followed by troublesome symptoms.
Low energy, low mood and irritability occur because of an imbalance within the methionine cycle due to an accumulation of Homocysteine in the Pathway. A buildup of homocysteine is the consequence, often worsened by a CBS mutation causing impaired homocysteine clearing. In many cases histamine can rise and breakdown can be impaired, further complicating this process.
CBS defects are actually upregulations (This means the enzyme works too fast). Neuroexcitatory and depression symptoms ensue with issues in the CBS and transsulfation resulting in incomplete ammonia-clearing by the urea cycle and reduced neurotransmitter formation. BH4 catalyzes the first step of the transsulfation pathway, from homocysteine to cystathionine. BH4 can also become depleted with a CBS upregulation, as BH4 helps regulate neurotransmitters and mood. Lack of BH4 can lead to mast cell degranulation and possibly mast cell activation disorder (MCAD). Therefore, it is common to see low levels of cystathionine and homocysteine since there is a rapid conversion to taurine which leads to high levels of ammonia.
Lastly, The NOS mutation can exacerbate ammonia issues. Furthermore, addressing CBS can help lower excessive levels of taurine and help detoxify ammonia. A great way to do this is with probiotics!
Clinicians should screen for conditions that may overwhelm transsulfation and detoxification pathways including infection, autoimmunity, toxic body burden, problems with blood sugar and fat metabolism and other inflammatory indications. Nutritional support, proper supplementation and stress and emotional management should be provided by a qualified provider, for mutations that are problematic for the individual. Continuing support and guidance should always be part of the plan!


The perils of Nitrous Oxide and MTHFR

The research is clear and indisputable that using Nitrous Oxide with a MTHFR SNP (mutation) puts those individuals at a higher risk for complications and death! In the last year, the news reported over 5 kids under the age of 8 who died receiving “routine” dental care. There is no need for another such sorrow!

As parents and genetic carriers of MTHFR, it is important to make our providers aware of our uniqueness. THIS should NEVER be disputed, if it is find another provider, there are lots of providers who are understanding and educated about MTHFR and will work with you and your mutation.

Nitrous oxide (N2O) has been used for well over 150 years in clinical dentistry for its analgesic and anxiolytic properties. It’s a simple inorganic chemical molecule has effects of analgesia, anti-anxiety, and anesthesia. Findings to date indicate that the analgesic effect of N2O is opioid in nature, and, like morphine, may involve a myriad of neuromodulators such as GABA and NMDA.

N2O is a known oxidizer of cobalamin (B12). Inhaling nitrous oxide halts methylation by inactivating the vitamin B12 reserves in the body, where natural B12 is rendered useless, unless there are adequate nutrients available to restore it back to its active and effective state. Vitamin B12 is essential for the maintenance of a healthy nervous system; because B12 and folate work together Folate is also destroyed by this process, compounded by a MTHFR mutation, which causes faulty methylation to begin with.

Decreased methylation activity results in increased homocysteine blood levels, which has been associated with changes blood vessel elasticity, increased coagulopathy and atherosclerosis in adults. Other research has demonstrated evidence of DNA changes in individuals with nitrous oxide exposures. Multiple studies have shown an increased sensitivity to anesthetics in the rapidly developing brain as well as the aged brain. These studies have even shown a long-term effect on learning. Currently, we lack a body of evidence about the long-term effects on health of workers exposed to chronic low levels of nitrous; this is an area that clearly needs more examination.

The symptoms of such damage vary, and have included severe weakness of the arms and legs in some, and in a handful of cases, episodes of mental illness. Treatment with high doses of B12 is effective, but some damage can be irreversible. It is likely that less severe vitamin B12 deficiencies caused by nitrous oxide overuse go undiagnosed, but cause milder symptoms, such as depression, forgetfulness and tiredness which may go uncorrelated to the N2O exposure.

Proper balance and function of both Methylfoalte and methylcobalamin are necessary for appropriate cell functioning as well as methylation and detox. Low levels of either due to faulty methylation or diet can put an individual at greater risk.

The Risk is highest for:
• Dentists and their staff who inhale second-hand gas all day long.
• Individuals with MTHFR polymorphism
• Individuals who are Vitamin B12 or folate deficient
• Individuals with any chronic condition/disease( ie. Lyme, autism, reflux, autoimmune diseases, to name a few)

In individuals with a COMT mutation as well could experience HIGHER pain levels with N2O; other mutations will cause a less desired outcome and may require higher dosing of N2O leading to further methylation damage.

Knowledge is always power, share your concerns with your provider and have an open dialogue about the risks and benefits for your particular situation!
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