Folate doesn’t cause Autism but folic acid might

folate-vs-folic-acid-1Naturally occurring folate, which is a water-soluble B9 (as found in leafy greens), is an important part of a healthy diet. Folate deficiency has been linked to osteoporosis, Alzheimer’s, infertility, heart attack, stroke, ulcers, macrocytic anemia, and other illnesses. Additionally, folate is critical for fetal development, and especially important for pregnant women. Folate aids in neural tube development, and can prevent severe birth defects of the spinal cord and brain.
Folic acid, is a synthetic form of folate manufactured in a lab..like pharmaceutical drug and is the form found in many fortified and enriched foods, and in multi-vitamins and of course in poor quality prenatal vitamins. A Norwegian study published last month found that heart-disease patients whose diets included folic acid fortification and supplementation were 43% more likely to die of cancer. Equally alarming is the study that found that folic acid supplementation by pregnant women increases the risk of childhood asthma by 26%…and now autism. Still other studies have linked folic acid supplementation to prostate and colorectal cancers.
Approximately 10 years ago most principled supplement companies made the leap to toss all folic acid from supplements and switch to MethylFolate. MethylFloate is the bioactive form or usable form of folate, the form the cells need to make energy and repair DNA, the same kind of DNA that parents give to their offspring. In the presence of a MTHFR MUTATION, the inability of the body to convert pharmaceutical folic acid to useable folate creates inflammation in the body and blocks up the pathways for the body to BE ABLE to utilize the nutritious form of folate. When this happens in the body, cells do not form properly and a deficiency ensues. Folate plays a critical role in formation of the spine of a fetus. When folate levels are low in a pregnancy, the fetus has a much greater risk of being born with spina bifida, or other neural tube defects; or more commonly a lip or tongue tie, or any other disorder that affects the undifferentiated cells in the “midline” during embryonic development.
Sadly many medical providers have used the terms folic acid and folate interchangeably. THEY are NOT the same. They do not react in the body the same and they do not produce the same outcomes. Many of the recent studies to associate correlation between autism and FOLIC ACID have mis- used the word folate. Have we gotten so far away from healing that now we should tell patients to STOP EATING GREEN VEGGIES…well I hope NOT? For many years I have urged patients to avoid supplements contain any sort of synthetic form of any vitamin. Whole foods and whole-food based supplements are the only places to get the nutrients and antioxidants that our bodies so desperately need.
The top 5 folate-containing green vegetables
• spinach
• romaine lettuce
• asparagus
• mustard greens
• collard greens

At this point, the recent study about Folate/folic acid and the correlation to autism, the evidence is extremely premature. However this study brought to light that blood tests done around the time of birth found that about 10 percent of mothers had excessively high levels of “folic acid/folate” and/or vitamin B12 in their blood. Interestingly this number correlates approximately with the number of women affected with homozygous c677t MTHFR (2 copies of the mutation or 10% function of the enzyme). Those people had an increased risk of having a child who would later be diagnosed with ASD. The findings have not been peer-reviewed or published in a journal; and is being presented at a conference this week. At the very least the media is focusing attention on this very important subject. We know the research will now focus on the distinction between folate and folic acid.

http://www.ncbi.nlm.nih.gov/pubmed/22648721

#mthfr #drkendrabecker #ilovewatchingyouheal

Extra Chromosome & Absent Enzyme; A look at Down Syndrome and MTHFR

Down Syndrome is a genetic mutation identified by an extra 21st chromosome. MTHFR is a genetic mutation identified by the absence of a vital enzyme essential for folate metabolism. There is an intimate connection between these 2 conditions, and by identifying MTHFR in children with Down Syndrome risks for many co-morbid conditions can be reduced or eliminated.
Contributing Factors
Environmental and Maternal Disposition. There has been recent research showing there is a higher incidence of children with Down syndrome born to mothers that are positive for MTHFR. Multiple polymorphisms were identified in this study which simply correlates the association. Practically speaking MTHFR mutations are seen in elevated levels in autism, spina bifida, fetal cardiac defects and Down syndrome. However, to solely implicate genetics in any medical condition is bad medicine. The environment plays such a large role in influencing our genes. Because of the role that MTHFR plays in folate metabolism and Homocysteine metabolism this association bears regard and acknowledgement.
It has been well researched that Children with Down Syndrome have higher incidences of:
Midline Development Issues
Heart defects. Almost one-half of babies with Down syndrome have congenital heart disease, the most common type of birth defect. MTHFR mutations are associated with a higher incidence of Heart Defects. MTHFR effects “midline development” the heart is an organ that develops form the midline in utero.
Hypothyroidism. Occurs more often in children with Down syndrome than in children without Down syndrome. Close evaluation of thyroid health, diet, supplements and possibly medication can assist in balancing this condition. Again, the thyroid is developed from the “midline” embryonic tissue. The same layer that is effected by the presence of MTHFR mutations. Research shows us children with Down syndrome are born to mothers with MTHFR mutations themselves. Genetics, and an extra chromosome leads to a much higher incidence of hypothyroidism.
Dental problems. Children with Down syndrome generally have a higher palate. This changes the landscape of the mouth and jaw and can cause teeth and speech development that differs from what is expected. Gum disease, is also very common. Gum Disease is well studied as a problem with digestion, bacteria imbalance and nutrient deficiency. MTHFR mutations are closely correlated with dental problems. Again, the gums and teeth develop from the “midline” during pregnancy. MTHFR mutations cause an “inefficiency” of folate metabolism. When this system is impaired the body uses additional vitamins and minerals (stored in the teeth and bones) to properly run its cycles. If nutrient levels are lower that the body’s demand the teeth and gums will suffer.
Sense Organs Issues
Vision problems. More than 60% of children with Down syndrome have vision problems. MTHFR defects can affect the eye. The vessels of the eye are so small that any kind of inflammation or excessive toxicity can “get stuck” in the small vessels of the eye and effect vision.
Hearing loss. About 75% of children with Down syndrome have some hearing loss, sometimes because of problems with ear structures. Children with Down syndrome also tend to get a lot of ear infections, due to narrow canals and anatomic variation which should be watched closely. MTHFR is more highly associated with sensory issues associated with hearing impairments.

Immunity and Blood Issue</strong>s
Infections. Kids with Down syndrome are 12 times more likely to die from untreated and unmonitored infections compared to kids without Down syndrome. The Immune system develops differently in kids with Down Syndrome, which can cause problem with immunity. This poses challenges with children and the current immunization schedule. In children with impaired immunity, vaccines can cause unanticipated reactions, which can lead to further health concerns. MTHFR and its ability to metabolize folate plays an intimate role in the immune system. These mutations can cause reduced immune function, bone marrow suppression and the inability to produce proper components of the immune system.
Blood disorders. Are common in children with Down syndrome. There is a 10 to 15 higher incidence of developing leukemia. Kids with Down Syndrome are at higher risk for a diagnosis of anemias of all kinds (low iron, low B12, high red blood cells, etc.). MTHFR is the enzyme that controls folate (B9) metabolism, however proper signaling of methylation, the pathway signaled by the MTHFR enzyme also requires proper interface with B!2 and B6, without these other B vitamins the pathway operates ineffectively and can further problems with anemias of all kinds.
Structural Issues
Hypotonia (poor muscle tone). Poor muscle tone and low strength is a common contributor to “delayed” milestones in Children with Down Syndrome. Low Tone can also effect nursing, swallowing, speech development, constipation and coordination.

Many of these problems can be addressed with skilled providers educated in the specificity of Down Syndrome Concerns. MTHFR pathways assist to eliminate toxins in the body. The benefit of an efficient elimination system means the body reduces its exposure to toxins and therefore reduces its potential for disease. Keeping MTHFR in good working order helps the body better balance muscle and strength development as well as reduce the problems associated with low tone.
Atlantoaxial Instability. Is present in 20% of children with Down syndrome. This is associated with an increased incidence of spinal cord injury and should be evaluated by a skilled provider for the best course of treatment. MTHFR is not associated with Atlantoaxial instability, however it is well reported that individuals with MTHFR have a higher incidence of damage to ligaments and tendons when ingesting “floxin” antibiotics. This should be thoroughly researched by any provider prescribing antibiotics to children with Down syndrome.
Digestion Absorption and Elimination
Digestive problems. Digestive problems in kids with Down syndrome, range from structural defects in the digestive system, food sensitivity or food allergy, and food aversions or addictions. Due to the metabolic and genetic components with Down syndrome very specific diets can be recommended and useful for a lifetime of healthy digestion, assimilation and weight balance. The research shows that approximately 80% of individuals with MTHFR have food allergy or food sensitivity. Remember that individuals with MTHFR have a harder time with detoxification where as individuals with Down syndrome have an impaired immune system.
Celiac disease. Is very common with Down syndrome. Celiac is an immune and gastrointestinal inability to digest the protein found in wheat and other grains containing gluten. Gluten should be completely avoided throughout a lifetime, this can be of benefit for a host of conditions that are associated and co-diagnosed along with Down syndrome. Individuals diagnoses with MTHFR have a 60% incidence of having Celiac disease as well. This is an important screening for all kids with any sort of immune dysregulation. Kids with Down syndrome can be susceptible earlier and with more severe symptoms.
Mental & Emotional
Mental health and emotional problems. There is a very high incidence of anxiety, depression, perseveration, and Attention Deficit Hyperactivity Disorder associated with Down syndrome. Individuals with MTHFR have higher incidence of anxiety, and depression. In some cases, the proper balance of specific B vitamins can improve symptoms in a very short timeframe avoiding medication and its problematic side effects.
Sleep disorders. Many children with Down syndrome have disordered sleep. This can be due in part to obstructive sleep apnea, narrow structures in the head and neck, food sensitivities or side effects of medication. MTHFR mutations can certainly cause issues with sleep. When folate metabolism is impaired a dysregulation in the body occurs. Also, effecting sleep can be B12 levels which can cause bedwetting, anxiety and restlessness

In conclusion Down syndrome and MTHFR are closely related and treating and supporting proper functioning of the MTHFR enzyme can dramatically improve outcomes or assist to avoid complications kids with Down syndrome may occur in their lifetime.
________________________________________
1. Bull, M. J., & the Committee on Genetics. (2011). Health supervision for children with Down syndrome. Pediatrics, 128, 393–406. [top]
2. So, S. A., Urbano, R. C., & Hodapp, R. M. (2007) Hospitalizations of infants and young children with Down syndrome: Evidence from inpatient person-records from a statewide administrative database. Journal of Intelle
3. Hardy, O., Worley, G., Lee, M. M., Chaing, S., Mackey, J., Crissman, B., et al. (2004). Hypothyroidism in Down syndrome: screening guidelines and testing methodology. American Journal of Medical Gen
4. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3078648/pdf/nihms-259545.pdf
5. http://www.sciencedirect.com/science/article/pii/S1110863015000889
6. https://www.ncbi.nlm.nih.gov/pubmed/11807890
7. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3168164/
8. http://ajcn.nutrition.org/content/70/4/429.long

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Lung infections and MTHFR; Chiropractic can help!

 

 

It has been widely reported that individuals with MTHFR are more susceptible to asthma and other lung infections. In the winter, particularly in New England bronchitis and pneumonia is rampant, even among our kids. Conventional medicine offers little to support these kids and usually leads them down a road of more steroids and antibiotics, increasing susceptibility.

Sadly, we know that many classes of antibiotics given to individuals with MTHFR can leave kids with more symptoms than when they were initially seeking treatment. Steroids, lifesaving in many cases, are often over- prescribed, assaulting immunity in our youth, and leading them down a road that requires steroids as their only treatment.

Chiropractic has been a mainstay in medicine for nearly 150 years. However in many cases, families believe that chiropractic is for “back pain” or “after a car accident”, yet the research shows us that chiropractic is very effective for many, many acute medical conditions as well!

The lungs have an extensive supply of nerves that communicate with them.  What would happen if there was interference with communication to the lungs? It may lead to respiratory problems, bronchitis or respiratory infections.  Several studies demonstrate the effectiveness of chiropractic care and improved respiratory function, breathing difficulty and bronchitis.

The premise of chiropractic is wellness and true prevention. So, the idea is we don’t get sick at all when under chiropractic care; however, stress, mal-adaption and dis-ease can set in to all of us!

Studies have shown chiropractic care is safe and effective, meaning proper adjustments can restore health sooner and more effectively than other modalities.  Especially in the presence of shortness of breath, asthma, allergies, coughing and hiccups!

One of the biggest symptoms that young children experience with pneumonia, asthma and bronchitis is air hunger. Air Hunger is the feeling that “you are running out of air”, it is part of the process of healing the lungs after an infection and it can last a few weeks! There is little conventional medicine can do     for this symptoms, but chiropractic can make a big difference.   In discussing such cases, the term “somatic dyspnea” is suggested to denote air hunger or shortness of breath related to somatic dysfunction.  Somatic dyspnea is a condition, which may accompany other causes of dyspnea (lung pathology, psychogenic or “functional” causes etc.)or can exist alone. There are multiple studies that prove, this symptom of air hunger was alleviated or abolished following the correction of vertebral subluxation complex or other somatic dysfunctions, aka, a chiropractic adjustment.  The response to chiropractic adjustments is sometimes so dramatic and rapid that patients may have an emotional response to taking their first FULL breath in a while!

The take home message is, first of all conventional therapies are useful in acute life threatening conditions or episodes. Secondly, individuals with MTHFR are likely more sensitive to everything; drug dosages, dis-ease, imbalance and environmental change. Thirdly, chiropractic is more than just for back pain; it’s useful in many acute conditions and can restore health and balance safely and effectively. Lastly, take care of your body, watch for signs of dis-ease, imbalance and illness and address them immediately!

Don’t make chiropractic or holistic medicine your “last resort “make it your first stop to better health!

 

 

 

 

 

Chiropractic adjustments of the cervicothoracic spine for the treatment of bronchitis with complications of atelectasis.  Hart, D.L. Libich, E, Ficher R. International Review of Chiropractic, 1991; Mar:31-33.

Chiropractic management of chronic obstructive pulmonary disease.  Masarsky CS, Weber M. Journal of Manipulative and Physiological Therapeutics, 1988; 11:505-510.

Adjustive osteopathic manipulative treatment in the elderly hospitalized with pneumonia: a pilot study. Noll DR, Shores J, Bryman PN, Masterson EV. Journal Of The American Osteopathic Association 1999; 99(3): 143-6

Somatic Dyspnea and the orthopedics of respiration.  Masarsky CS, Weber M Chiropractic Technique, 1991; 3:26-29

Specific upper cervical chiropractic care and lung function.  , R Abstracts from the 13th annual upper cervical spine conference, Nov 16-17, 1996 Life College, Marietta, Georgia.  Pub in Chiropractic Research Journal, Vol. 1V, No.1, Spring 1997 p.27 (also Kessinger R; Changes in pulmonary function associated with upper cervical specific chiropractic care J Vertebral Subluxation Research 1997; 1(3):43-9.

 

Antibiotics and The Gut…again.

In society today antibiotics are overly prescribed. Most patients receive the advice to “take all medication as prescribed” however, in some cases that not be the case. It is ALWAYS imperative to discuss with the prescriber when changing a treatment plan but there may be more occasions than not, to discontinue antibiotics before the “last pill was taken”.

The failure of the medical community to appropriately utilize antibiotics in the 20th century has left us with many antibiotic resistant microbes plaguing patients at younger and younger ages.  Many prescribers prescribe to a “quick fix medicine” and in many cases abused and misused antibiotics in the name of “protocol”.  Of course this comes back to the fundamental disconnect between pharma and health. So it is imperative patients and parents advocate for themselves in these sorts of situations.

Antibiotics, like food are broken down and digested by the body. Long term or frequent use of antibiotics alter the proper digestive bacteria in the gut and reduce the digestion and assimilation of these pharmaceuticals. This means that active and Un-Metabolized antibiotic by-products, which retain antimicrobial activity, will be excreted into the environment compounding our issues with antibiotic resistance.  Even though an antibiotic is prescribed an for 7 days, does not mean that “bad bacteria” are only exposed to it for 7 days; normal gut flora (and potentially the pathogen) will continue to be exposed to the antibiotic and it’s by- products for some time after completion of therapy. The US contributes more than 17,000 tons of antibiotics into the environment every year in the United States alone (80% for agriculture, 20% for human use).

Compounding this issue is the antibiotics found in our food. This too builds resistance to microbes and accelerates the problems with prescribing. Be a savvy consumer and choose with your dollars. Buy local, organic and avoid processed or packaged products. Ultimately your gut and the rest of your body will thank you for it.

There is a time and place for all things medical, however the research over and over has shown that antibiotics as a first line of treatment may not be as effective or useful as previously revealed. Any and all pharmaceuticals will disrupt normal function of the gut, temporarily or permanently. Be sure to utilize them wisely and replete the gut with beneficial probiotics after use, discuss with your provider the shortest most optimal course of action for your condition and your lifestyle.

For more information and healthy recipes to heal the gut check out my book

 

 

http://www.medscape.com/viewarticle/871856?src=WNL_infoc_161120_MSCPEDIT_TEMP2&uac=127670EJ&impID=1238355&faf=1

http://dhs.unr.edu/Documents/dhs/chs/NVPHTC/The%20New%20Antibiotic%20Mantra%E2%80%94%E2%80%9CShorter%20Is%20Better%E2%80%9D.pdf

Warrior or Worrier? The truth about COMT

 

Catechol-O-methyltransferase (COMT) is one of several enzymes that degrade catecholamines such as dopamine, epinephrine, and norepinephrine. In humans, catechol-O-methyltransferase protein is encoded by the COMT gene. COMT is mostly found in the peripheral nervous system, and less significantly found in the Central Nervous System, and found in the highest concentration in the liver.

 

There are 2 types of COMT expression, the warrior and the worrier.

 

Warrior

Generally have a higher IQ

do better on tests

better toxin elimination

higher estrogen elimination

higher incidence of ADHD

Higher pain tolerance

Normal magnesium levels

Normalized B12 and folate levels

Even tempered

Worrier

Slower estrogen elimination and estrogen dominance
Lower pain tolerance

Increased probability of addiction and anorexia

PMS worse in females

Enhanced response to stimulants

Red face after exercise & Decreased Sweating

Lower Mg levels

Lower Intracellular b12 and folate

Prone to mood swings and mania

 

 

 

 

 

 

 

COMT is the enzyme that allows you to spare the “feel good hormones” dopamine and nor-epinephrine. If this enzyme is completely blocked mood swings and addiction can occur. Keeping the gut healthy with probiotics and a good diet assures proper conversion of the amino acids needed to manufacture quality neurotransmitters. Lots of antibiotics and processed food can impair digestion and create impairments in conversion and manufacturing.

One of the most important jobs that COMT has, is to degrade dopamine, in the brain, where it is broken down by MAO (monoamine oxidase). MAO is Another important snp/gene that encodes an enzyme partially responsible for the metabolism of several neurotransmitters such as dopamine and serotonin. The monoamine oxidase family of enzymes, metabolize monoamines (neurotransmitters and neuromodulators consisting of a single amine).

COMT is the enzyme that introduces a methyl group to the catecholamine, which is donated by S-adenosyl methionine (SAM). Any compound having a catechol structure, like catecholestrogens and catechol-containing flavonoids, are substrates of COMT. This is why individuals with a COMT mutation are considered estrogen sensitive and estrogen dominant.

By discussing and understanding the biochemistry and intricacies of the COMT enzyme we can begin to see the problems with it when individuals have missing or reduced functioning.

COMT mutations cause great difficulty with detoxing. COMT pathways toss out good and bad minerals indiscriminately leaving low level magnesium (among others), an essential mineral to uptake b12 properly.  B12 levels can be supplemented with success using lithium orotate, please check with a provider about dosing. Supplementing with lithium to enhance transport may in fact cause a b12 deficiency if its not done properly.

Individuals with a COMT mutation are generally volatile susceptible to depression, mood disorders and issues with toxicity.  This means be mindful of your stress and moods and put some supports in place during times of physical and emotional stress. Addiction is common with individuals carrying this SNP too, I highly recommend early and often discussions around drugs, alcohol and other addictive substances or behaviors.

 

COMT mutations can make people sensitive to phenols. Phenols are found in purple and red foods, such as strawberries and red grapes, these slow the function of the enzyme further. When the COMT enzyme slows there can be mood swings, insomnia or anxiety. Symptoms of people with phenol sensitivities are heat intolerant suffer from headaches and insomnia.

 

In a nutshell, individuals with COMT mutations require individualized, targeted treatment and should be addressed on all facets of wellness!

 

 

 

 

 

 

 

 

 

 

 

Autism and the other A’s (allergies, asthma and atopy/eczema)

the-atopid-triad

Why is it that many autistic children struggle with a lot of other “A”s?

  • Statistics show 25% of kids with autism has asthma too.
  • Statistics show 60% of kids with autism has eczema too.
  • Statistics show 8% of kids with autism has anaphylactic allergies and 40% have seasonal allergies.

Although there are multiple mechanisms for these conditions individually, the focus for this article is the global impairment of the immune system that predisposes kids with autism to other conditions.

The research shows that autistic kids are overburdened with all kinds of immune imbalance. This immune system imbalance initiates improper reactions to toxicity and how the body attempts to make every effort toward elimination (of toxins). Autistic kids have impaired detox mechanisms and altered methylation pathways, which are integral for detox of harmful substances the body comes in contact with frequently. Methylation is an important step in the detoxification of the body, and requires active forms of certain B vitamins in order to function optimally. When methylation is impaired detoxification is impairs and the body is overburdened, sending out signals that the immune system must be prepared for attack. “Attack Mode” for the immune system causes a overwhelming immune response to a normal circumstance.

Allergies…It is not biologically normal to react to food. Food is nourishment and provides the body with essential building blocks for all components to body function. When the body starts to react to its environment (and food) MAST cells are released. MAST cells release histamine, a chemokine that activates gut and brain neurotransmitters resulting in an “ITCH”. Histamine’s job is to activate white blood cells (WBCs) to stop foreign invaders, but when histamine is released by MAST cells that are activated in the absence of pathogens, the body begins fighting its environment. This rebellion causes global histamine imbalance in the body which sends the “ITCH” everywhere!

Imagine if you had an itch in your brain or gut that you couldn’t scratch..that’s how I imagine autistic kids feel every day!

When histamine is high, life altering symptoms can occur, and let’s not discount that histamine has a very vital job in the immune system, but;

  • If histamine is high in the skin >> eczema
  • If histamine is high in the lungs >> asthma
  • If histamine is high in the brain >> mood changes
  • If histamine is high in the gut >> allergies

STOP THIS MADNESS and heal the gut!!

  • Start by removing any chemicals or foods that trigger imbalance.
  • Consider probiotics (but discuss which strains or formulations are best for you).
  • Consider the removal of any and all potential allergens like molds, yeasts, preservatives, chemicals and sugars (which paralyze the immune system, later causing an over shoot and furthering improper balance), for the environment. Of course in most cases this cannot be done overnight but slowly phasing out will improve symptoms quickly!

Once the body is healed, as each healing process is different; many previously offending agents may be able to be reintroduced back into the environment! Make simple and effective changes, support body balance and start your healing today.

https://www.ncbi.nlm.nih.gov/pubmed/24997632

http://www.medscape.com/viewarticle/721702_2

http://emedicine.medscape.com/article/912781-treatment#d10

 

 

 

 

Common MTHFR Mutations and General Health

mthfr

What is a MTHFR Mutation? An abnormal change in gene structure/mutation, of the MTHFR gene can cause a disruption of the MTHFR enzyme’s normal function of breaking down homocysteine.

MTHFR mutations are common. The mutations can be “heterozygous” meaning they occur only on one strand or “allele” of the chromosome, or they can be “homozygous”, occurring on both alleles. The frequency of a mutation is common, occurring in about 60% of the population. MTHFR gene is directly related to hyperhomocysteinemia (high or elevated levels of homocysteine).

High levels of homocysteine can be attributed to many conditions seen in midwifery such as

  • Decrease in vitamin B-12 levels. Higher incidence of anemia
  • Complications in Pregnancy Due To Neural Tube Defects, posterior Tongue tie, lip tie
  • Anencephaly
  • Other neural tube defects
  • Spina bifida
  • Autism
  • Rheumatoid Arthritis Flares
  • Down Syndrome
  • PEs
  • Altered drug metabolism
  • Low vitamin d levels/ osteoporosis
  • Neuropsychiatric Disorders
  • Gestational Diabetes
  • Early Pregnancy Loss/ SAB (viable fetus)
  • Placental Abruption, Low Birth Weight

The most common MTHFR gene mutations are found at position 677 and/or position 1298 on the MTHFR gene.

Typical amino acids are replaced by others rendering the enzyme defective or inactive

  • MTHFR 677CC = a normal MTHFR gene
  • MTHFR 677CT = a heterozygous mutation which is one mutation
  • MTHFR 677TT = a homozygous mutation which is two mutations
  • MTHFR 1298AA = a normal MTHFR gene
  • MTHFR 1298AC = a heterozygous mutation which is one mutation
  • MTHFR 1298CC = a homozygous mutation which is two mutations
  • MTHFR 677CT + MTHFR 1298AC = a compound heterozygous mutation which is one mutation from two different parts of the gene

MTHFR 677TT + MTHFR 1298CC= DOUBLE Compound Heterozygus

folate-vs-folic-acid-1

Treatment: (of course always speak with a knowledgeable provider)

May or may not include.

  • Getting you or your family members tested (blood, saliva)
  • Avoiding all forms of synthetic folic acid and un-methlyated B vitamins like cyanoB12
  • Folic acid does NOT equal Folate.
    • Folic Acid a synthetic type of Folate. Folic acid is not found in nature. Folic acid must undergo various transformations prior to utilization.
  • Being mindful of all pharmacology and vaccines
    • Antacids (deplete B12)
    • Cholestyramine (deplete cobalamin and folate absorption) – common in gallbladder issues during pregnancy!
    • Colestipol (decrease cobalamin and folate absorption)
    • Methotrexate (inhibits DHFR)
    • Nitrous Oxide (inactivates MS)
    • High Dose Niacin (depletes SAMe and limits pyridoxal kinase = active B6)
    • Theophylline (limits pyridoxal kinase = active B6)
    • Cyclosporin A (decreases renal function and increases Hcy)
    • Metformin (decreases cobalamin absorption)
    • Phenytoin (folate antagonist)
    • Carbamazepine (folate antagonist)
    • Oral Contraceptives (deplete folate)
    • Antimalarials JPC-2056, Pyrimethamine, Proguanil (inhibits DHFR)
    • Antibiotic Trimethoprim (inhibits DHFR)
    • Ethanol
    • Bactrim (inhibits DHFR)
    • Sulfasalazine (inhibits DHFR)
    • Triamterene (inhibits DHFR)
  • Involving yourself with providers who are educated on MTHFR
  • Take supplements that are methylation supportive
    • L-5-MTHF
    • Riboflavin (B2)
    • Methylcobalamin or Hydroxocobalamin
    • Zinc
    • DHA
    • Choline
    • TMG (must be avoided in pregnancy)
    • Magnesium
    • Methyl- B6
    • NAC
    • Vitamin E (natural forms only)
    • Selenium
    • Glutathione
    • Vitamin C
    • Vitamin D
    • Potassium
    • Probiotics
    • Molybdenum
    • Milk Thistle
    • *****Avoid gluten as 20% of patients with MTHFR have gluten sensitivity and gluten is inflammatory

 

What a post-partum mom really wants when you visit her and her baby

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Truth is visits from well-meaning family and friends are always welcome! It’s the unsolicited advice or subtle (pressured) offers to hold/ care for the newborn we could all do without. Research has shown us time and again that the first weeks of life are critical for bonding, proper milk supply and post-partum recovery of the mother.

The best things we can do for mom and her new baby is:

1) Take their other kids somewhere. Older siblings are usually under stimulated by the daily goings on of a newborn. So take the other children for as long as you can, and bring them back exhausted and fed.

2) Feed the mama! Remember she is constantly feeding another human! Be sure to check with here to see if there are particular things she is or isn’t eating. Be sure the dish is disposable or a gift. Post-partum moms do not have the best memory capacity.

3) Collect some cash or a gift card for cleaning services! Who has time for cleaning after you have just spawned a human from your loins! Find a trusted service or person to do the job! Worth every cent!

4) Offer to watch the baby while mom naps or showers. Both those items become scarce in the immediate post-partum period. A few minutes of your time are a huge gift to a tired or smelly mama!

5) Help to recognize signs of postpartum depression. “Baby Blues” can last 6 weeks, anything beyond that that could be cause for concern should be addressed and guided to the proper provider. As you all know regular chiropractic has been shown to reduce post-partum depression. Be Sure to on the lookout for tell-tell signs that mama might be struggling.

6) Invite mamma and baby to get out of the house. We all know what kind of Olympic sport it is to get a newborn fed, changed and clothed to get out; help her get a change of scenery, even if it is only a short walk around the block.

7) Offer to run errands for her, do her grocery shopping in person or online, pick up a few items at the coop, grab that homeopathic for the baby’s prickly stomach (remember #6) it is likely she will gladly accept the help.

8) Make a sign for their door that says “Baby Sleeping” or “please come in..and do some laundry” in early postpartum days sleep is precious get any and all you can! And avoid being disturbed by the UPS guy or the neighbor’s kids who want to play.

Truth is we have all been there and we all need the help. This is an amazing way as women we can support each other and grow together. When mama is recovered she will be ready to help you with your bundle of joy!

Autism healing begins in the Gut!

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It has been well reported that autism is intimately connected to the immune system and acts in some way as an autoimmune conditon. Immunity begins to develop during the 14th week of gestation, as undifferentiated developing immune cells, which later become major cells of a human’s immune system, with specific and necessary function. The placenta, provides nourishment for the baby, also secretes hormones, primarily progesterone, which shifts mom’s chemical profile away from Th1 (offers protection to pathogens that pose a threat to get inside of cells) and towards Th2 (response offers protection against pathogens outside of cells).  The baby then will trigger his/her increase in Th1 when travelling through the birth canal and swallowing, sitting and slipping through on its earth side voyage. The development of the Th1 mechanism is continued during breastfeeding, for which the “World Health Organization” recommends at least 2 years, to glean all the necessary immunologic benefits for the baby.  Continued, through childhood with encounters from viruses and bacteria help build this individualized Th1 response to properly enhance the child’s immune system. If at birth immunity is skewed toward Th2, for such reasons as a c- section, multiple exposures to antibiotics in utero or mother receiving passive immunity exposure, breastfeeding is interrupted or cut short; Th2 is accelerated and can predispose a baby toward eczema.  If the baby is prone toward a Th2 response, as they were unable to develop a proper microbiome, autism can be triggered or allergies and asthma may also develop.

The answer to the triggers for these conditions may be found in the gut bacteria that babies are gifted on their way down the birth canal. Since we know, One third of all antibiotic prescriptions given to children are unnecessary (according to medical research). Antibiotics are well reported to disrupt a child’s gut microbiome in ways that a growing amount of evidence suggests may have long-term consequences, including asthma, allergies, and eczema.

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Balancing gut bacteria with proper diet free of chemicals, processed foods, irritants and GMOs help balance the biome. Identifying triggers and reducing or eliminating passive immunity can also help improve these conditions. When a body is inclined toward a Th2 response, the cells will “over react”, with an inflammation response. Passive immunity such as vaccination bypasses the Gut and triggers this over response in the blood stream. This compounds the “inflammation” cascade and revs up the immune system in an “autoimmune” fashion creating a global multi-faceted reaction that will prone the body toward constant “reaction” as seen in eczema, allergies and asthma.

Conventinal Pharmecutical modalities may cause additional “stress” to the body, and since stress and stress hormones can elevate inflammation, they are intimately related.

Autism is rising at epidemic rates with some prognostication that 50% of our children will have autism in the next generation!

Some easy tips to get started on healing the gut and rebuilding your microbiome are:

  • Eliminate inflammatory chemicals in your environment; start with anything with a scent and replace them with non-toxic bio degradable choices
  • Eliminate inflammatory foods such as Dairy, Wheat, Corn, Soy; these are the most common food triggers associated with autism, asthma, allergies, and eczema
  • Eliminate GMOs; these chemicals are not digested or assimilated well in a healthy gut, worse for one that needs healing
  • Use only products you can eat on your skin, like coconut oil, avocado or shea butter for example
  • Check Lab work with a qualified provider, check immune markers, MTHFR status, stress hormones, vitamin and mineral levels; all of which play into the inflammation cycle.
  • Remember there is no one size fits all approach; every child is different and every healing process is different

http://dx.doi.org/10.1016/j.chom.2015.04.006

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2684040/

B12…not always created equally

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B12 is important to build red blood cells and nerves. It also supports proper DNA development. Most individuals who are vitamin B12 deficient on lab work, have  some preexisting condition, such as gastritis, auto immune disease, take multiple medications that deplete b12 stores or are malnourished.  Vitamin B12 tests are not the most accurate way of telling how the cells are utilizing b12, or if they are utilizing it at all. So, in fact individuals with adequate numbers on lab work could actually be deficient.  In the presence of MTHFR, B12 can look adequate or even elevated on lab work but be completely depleted inside the cell where the B12 is needed most.

Experiencing any of the symptoms on this list could mean there is a B12 deficiency in the body

  • Light-headedness, tiredness and fatigue
  • Shortness of breath and elevated heart rate
  • Poor concentration and memory
  • Tingling and numbness of the feet and hands
  • Lack of coordination and balance
  • Diagnosis of persistent anemia
  • Excessively pale skin
  • Sore tongue
  • Rash around the mouth
  • Bleeding gums and easy bruising
  • Upset stomach
  • Abnormal weight loss or gain
  • Hallucinations, depression, mania and irritability

 

Adequately Inadequate vitamin B12 intake

For individuals with a MTHFR mutation, B12 absorption and utilization is faulty. Individuals with any issue with digestion B12 absorption are impaired. In order to make the proper amounts of stomach acid, B12 is needed as a cofactor. Without this digestion IS impaired. Vegan and vegetarian diets are deficient in B12, posing a greater risk of deficiency in individuals with MTHFR, this can lead to other nutrient deficiencies and health problems.

The best foods for boosting B12 are

  • Clams and beef liver
  • Eggs, fish, poultry, meat, milk and other dairy products
  • Nutritional yeasts, some cereals and other fortified foods

 

Suspect B12 deficiency with any of the conditions listed

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  • Anemia with elevated mean corpuscular volume or Pernicious anemia
  • Balance issue, numbness, difficulty with walking, tingling and other neurological symptoms
  • Gastritis, Celiac Disease
  • Food sensitivities
  • Alzheimer’s disease and dementia
  • Any chronic inflammatory bowel disorder
  • Vegetarians and vegans
  • Autoimmune disorders
  • Developmental delay and autism
  • Use of “poly pharmacy” drugs such as SSRIs, Metformin and PPIs
  • Vascular disorders such as blood clots, stroke or heart attack

 

B12 deficiency…all B12s are not created equal

It is important to understand that treatment is not a “one size fits all” approach. Not all B12 will react the same in each body depending on SNP expression; there are the 4 Types of B12. Of course its optimal to get the bulk of B12 from the diet, however in cases of deficiency or unrelenting symptoms proper supplementation can help.

Adenosylcobalamin is naturally occurring, but, it is the least stable of the four types of B12 outside the human body and does not translate well into a tablet-based supplement. This is best for individuals who are sensitive to other forms of B12 and require a highly absorbable form of supplementation.

Cyanocobalamin is a synthetic, pharmaceutical version of vitamin B12 is created in a lab. It’s cheap and utilized most often by prescribers, who prescribe B12 for a deficiency. When it metabolizes in the body it breaks the cyano- molecule (cyanide, yes cyanide) off to be absorbed by the body.  Although the amount of cyanide is not dangerous, it does require extra energy of the body to eliminate it from the cells. Extra toxin elimination is not optimal for anyone with methylation challenges.

Hydroxocobalamin is naturally created by bacteria. Hydroxyocobalamin is the form of vitamin B12 most likely found in food; it easily converts into methylcobalamin in the body. Hydroxocobalamin is commonly used in individuals who do not tolerate methylcobalamin supplementation and as a treatment for cyanide (yes, cyanide) poisoning.

Methylcobalamin  is the most active form of B12 in the human body. It converts homocysteine into methionine, which helps protect the cardiovascular system. Methylcobalamin also offers overall protection to the nervous system. Methylcobalamin can cross the blood-brain barrier, this helps to protect and heal the brain. Methylcobalamin is essential for detoxification and as a catalyst for many of the body’s biochemical reactions.

With nearly 40% of Americans having trouble absorbing B12; selecting the proper form of B12 can be tricky business. Absorption of B12 is heavily reliant of digestive health, get digestion working properly and find a provider savvy enough to assess and prescribe the right B12 for your body.

This information is not to be used as a substitute for medical advice, diagnosis or treatment of any health condition or problem.  Any questions regarding your own health should be addressed to your own primary care physician or other healthcare provider.