MTHFR & Male Fertility

Daddy’s Genes Matter!!
So much of the focus on Fertility and MTHFR falls on the mother and her genetic contribution. However 50% of the baby’s genome comes from DAD! We evaluate and scrutinize mom’s diet and yet dad is left alone!

Recently powerful new research on MTHFR mutations and miscarriages implicates the fathers role more than we thought possible. While each parent contributes equal DNA to their offspring, it is women, mothers that come to office visits and comply with recommendations. Next time ladies! Bring your man!

A recent large scale study proved correlation that BOTH the MTHFR C677T and the A1298C contributed from BOTH parents increased risk of miscarriage. Interestingly, babies with 2 copies of the MTHFR A1298c mutation had the highest incidence of miscarriage. 2 copies of a mutation means EACH parent donated one copy! DAD’s Genes matter too!

So here at the FWC our preconception health protocol includes BOTH parents! And the “inception” of the protocol is months before “conception”. A thorough review of lab work, medical conditions, diet, lifestyle and genetics assist in the best possible outcomes.

It is important to note when addressing conception and MTHFR that a good quality diet and proper nutrients including bio-available Folate is included. Folate is what ensures proper functioning DNA and provides the proper signaling for cell differentiation in early pregnancy, as well as protecting sex-cells in BOTH parents from DNA damage. However, Choosing Folate alone will not eliminate poor outcomes.

However we do know Low folate levels are associated with higher incidence of:
• Miscarriage
• Low sperm quality
• Autism
• ADD/ADHD
• Allergies
• Among other conditions
Getting Started!
Begin your road to parenthood months before conceiving. Give the PALEO diet a try. Paleo is a diet chuck full of nutrients and beneficial fat and free of many common allergens and chemicals.
Normalize weight and maintain exercise to help ensure proper function of metabolism, sleep cycles and menstrual cycles (for mama only of course in this instance).
Meet with an educated provider who can run proper lab testing and make recommendations to optimize the best pregnancy outcomes. Remind providers (or find another) that Folic acid is not the optimal form of folate for properly functioning DNA especially in the presence of MTHFR mutation.
Enjoy the journey; becoming a parent is one of the most amazing experiences in a lifetime.

MTHFR..an introduction

Faulty methylation has been linked to heart disease, stroke, reproductive disorders, neurodegenerative diseases like Alzheimer’s, Parkinson’s, ADHD, Autism Spectrum Disorders and fertility issues. It has also been linked to chronic fatigue, anxiety, depression, colon cancer, reproductive cancers, kidney infarct, cervical dysplasia, faulty detoxification and impaired DNA repair.

Methylation occurs when SAMe (S-adenosine methionine) donates a methyl group, which is then attached to the molecule that is being detoxified. SAMe then becomes homocysteine.
Vitamin B6, B12, and folate are necessary to reduce homocysteine and keep the methylation process occurring smoothly.
Methylation is also used in DNA regulation. If you have poor methylation, your cells will not function correctly leading to decline in health.

• MTHFR (Methylenetetrahydrofolate reductase) It is first converted to tetrahydrofolate (THF) then to 5,10-methyleneTHF. MTHFR is needed to further convert 5,10-methyleneTHF into active 5-methylTHF, in order to convert methionine from homocysteine.
• MTR – 5-methyltetrahydrofolate-homocysteine methyltransferase is encoded by the MTR gene. It’s task is to regenerate methionine from homocysteine by using 5-Methyl-THF(levomefolic acid obtained from MTHFR conversion) as a methyl donor. Vitamin B12 is needed.
• MTRR – this gene provides instructions for making methionine synthase reductase. Methionine synthase helps process amino acids, which are the building blocks of proteins. Specifically, it converts the amino acid homocysteine to methionine.
• COMT – catalyzes the transfer of the functional methyl group from S-adenosylmethionine (SAMe) to the desired substrate. COMT snps can cause Impaired neurotransmitter metabolism, Decreased drug metabolism, Decreased detoxification of toxic catecholamine’s from the environment. Correlated with a variety of human disorders, including estrogen-induced cancers, Parkinson’s disease, depression, and hypertension.
• HOMOCYSTEINE- A modified amino acid that is toxic at elevated levels. In high levels can lead to many of the disorders. Homocysteine is not obtained from the diet; For treatment to be effective, levels should be monitored and genetics should be evaluated to properly lower homocysteine.

MTHFR and Chiropractic

 

Recently there has been a lot of talk about MTHFR (methylenetetrahydrofolate reductase gene that contains the DNA code to produce the MTHFR enzyme. This enzyme, simply stated, helps us convert B vitamins into energy inside the cells) When there are mutations or variations in the MTHFR gene, there is enzymatic malfunction or decreased function, this is implicated in everything from serious genetic disorders to no so serious nuisance type problems.
Because MTHFR is genetic, and appears in 60% of the population, there is little we can do about what passes to us from our parents, but a host of things we can do to support functioning of this enzyme and support the proper energy production.
Many factors related to MTHFR, can cause a person to become deficient in vitamins, minerals, amino acids and antioxidants; and conversely have higher levels of inflammation. So the standard clean diet, good sleep, exercise and of course chiropractic apply here..however chiropractic can also be a useful tool in detection of a MTHFR problem.
Nutrient deficiency symptoms vary, but are very apparent to a physician educated about MTHFR. Deficiencies in calcium, magnesium, zinc, N-acetyl cysteine (NAC), glutathione, iron and vitamins B1, B2, B6, B9 (folate), B12, and Vitamin D very common with MTHFR, and can effect chiropractic care. Many of these deficiencies can affect how we heal, perceive pain and even how an individual holds adjustments.
Science has shown us time and again that low Vitamin D levels affect mood and increase pain, low levels of minerals cause muscle spasms, poor sleep and anxiety, and low levels of B vitamins increase our susceptibility to toxins and oxidative stress…all things patients visit the chiropractor for!
In the meantime don’t start guessing where you’re deficient and taking supplements randomly. Listen to your body:

Is your fatigue unrelenting even after treatment? This could mean that your MTHFR mutation gives you the inability to utilize B vitamins properly, and your cells are “starving” for energy.

Are you holding your chiropractic adjustments? If not it is likely your MTHFR issue is causing low mineral levels in your cells.

Are you constantly getting injured or taking an extra-long time to recover? It is likely your levels of inflammation are higher; this alone can lead to long term damage and should be addressed in a timely fashion.

Of course, the best approach is proper diagnosis and treatment by a skilled provider who can educate and empower your healing. Eat well, Sleep Well and of course TURN YOUR POWER ON!!
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