Extra Chromosome & Absent Enzyme; A look at Down Syndrome and MTHFR

Down Syndrome is a genetic mutation identified by an extra 21st chromosome. MTHFR is a genetic mutation identified by the absence of a vital enzyme essential for folate metabolism. There is an intimate connection between these 2 conditions, and by identifying MTHFR in children with Down Syndrome risks for many co-morbid conditions can be reduced or eliminated. Contributing Factors • Environmental and Maternal Disposition. There has been recent research showing there is a higher incidence of children with Down syndrome born to mothers that are positive for MTHFR. Multiple polymorphisms were identified in this study which simply correlates the association. Practically speaking MTHFR mutations are seen in elevated levels in autism, spina bifida, fetal cardiac defects and Down syndrome. However, to solely implicate genetics in any medical condition is bad medicine. The environment plays such a large role in influencing our genes. Because of the role that MTHFR plays in folate metabolism and Homocysteine metabolism this association bears regard and acknowledgement. It has been...
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Warrior or Worrier? The truth about COMT

Warrior or Worrier? The truth about COMT

  Catechol-O-methyltransferase (COMT) is one of several enzymes that degrade catecholamines such as dopamine, epinephrine, and norepinephrine. In humans, catechol-O-methyltransferase protein is encoded by the COMT gene. COMT is mostly found in the peripheral nervous system, and less significantly found in the Central Nervous System, and found in the highest concentration in the liver.   There are 2 types of COMT expression, the warrior and the worrier.   Warrior Generally have a higher IQ do better on tests better toxin elimination higher estrogen elimination higher incidence of ADHD Higher pain tolerance Normal magnesium levels Normalized B12 and folate levels Even tempered Worrier Slower estrogen elimination and estrogen dominance Lower pain tolerance Increased probability of addiction and anorexia PMS worse in females Enhanced response to stimulants Red face after exercise & Decreased Sweating Lower Mg levels Lower Intracellular b12 and folate Prone to mood swings and mania               COMT is the enzyme that allows you to spare the “feel good hormones” dopamine and nor-epinephrine. If this enzyme is completely blocked mood swings and addiction can occur. Keeping the gut healthy with probiotics and a good diet assures proper conversion of...
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